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To acquire energy, FA activation is a must, where FAs are converted into acyl-CoA by the acyl-CoA synthetase on the outer mitochondrial membrane, followed by entering mitochondria with the assistance of carnitine palmitoyltransferase 1 (CPT1) on the outer mitochondrial membrane together with carnitine-acylcarnitine translocase (CACT) and carnitine palmitoyltransferase 2 (CPT2) on the inner membrane [112]

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[PUBMED Abstract] Sternberg CN, de Bono JS, Chi KN, et al.: Improved outcomes in elderly patients with metastatic castration-resistant prostate cancer treated with the androgen receptor inhibitor enzalutamide: results from the phase III AFFIRM trial

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