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Paradoxically, reduction of intestinal GIP expression [93], GIPR antagonism [94] or genetic elimination of GIPR [95], also reduces food intake and promotes resistance to diet-induced obesity and weight loss in multiple species

[DOI] [PubMed] [Google Scholar] 78.Stromsdorfer K.L., Yamaguchi S., Yoon M.J., Moseley A.C., Franczyk M.P., Kelly S.C., Qi N., Imai S., Yoshino J

This was a landmark finding because it established that a weight loss medication could provide cardiovascular protection independent of diabetes status

Increasingly, obesity may be seen less as a personal failing and more as a medical condition, like type 2 diabetes or high cholesterol, warranting comprehensive treatment

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Your body composition changes even when the overall weight stays the same