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The inhibitors designed to target one specific isoform may inadvertently affect others, causing unintended interactions or side effects and complicating their therapeutic use

Curr Opin Virol 18:5056

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The best powered of these studies examined genetic variation in 42 genes (308 single nucleotide polymorphisms (SNPs)) related to glutathione, including those coding for enzymes that use glutathione as a co-factor (not included in this review), in 318 families from the Autism Genetic Resource Exchange repository [87]

Pasca S, Dronca E, Kaucsar T, Craciun EC, Endreffy E, Ferencz BK, Iftene F, Benga I, Cornean R, Banerjee R, Dronca M: One carbon metabolism disturbances and the C677T MTHFR gene polymprhism in children with autism stpectrum disorders