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Research on the PLOD1 gene mutation in Kyphoscoliotic EDS proved that a total failure to hydroxylate L-Lysine results in a complete absence of collagen cross-links, leading to severe hypermobility and tissue fragility

Sampson JA: Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity

Requires 1.5ml per leg (0.75ml per side) for full coverage

More serious side effects include spasms of the vocal cords, obstruction of the airway, and sleep apnea

Occasionally however, the mark left behind is either in a particularly bad place (like the face) or heals with an unacceptably bad scar

Is Sembolic safe during pregnancy or breastfeeding