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Renal capillaries are considered to be easily damaged by hyperglycemia and hypertension, the major causes of kidney disease, and capillary damage provokes IRI [12]

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Despite causing an increased susceptibility to OS, G6PD deficiency may also protect against CVD, since NADPH is an essential cofactor for enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA R), and G6PD deficiency or NADPH deficiency may restrain HMG-CoA R activity similarly to statins (Fig