Although the human body naturally produces glutathione, factors such as age and poor diet can cause the levels of this essential antioxidant to decrease
This turnover, under control of the proteasomal system, is essential in the setting of physiologically stressful conditions such as chronic myocardial ischemia
Nevertheless, systemic administration of DAMP inhibitors results in extensive drug distribution, which may inadvertently interfere with the physiological functions of DAMPs in healthy tissues
In rat with the treatment of 10 g/Kg/day BPC 157, the concentration of BPC 157 was estimated to be less than 1 g/ml in the blood which was too low to cause hypotension or hemodynamic change as demonstrated by the lack of vasodilation in the present study 6
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Glutathione S-Transferase in Mucus of Rat Small Intestine