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Similarly, when vitamin B12 forms are given to deficient patients and interact with biological agents such as nicotinamide adenine dinucleotide phosphate, flavin mononucleotide, or flavin adenine dinucleotide, the Co-C and Co-O bonds break, and the central cobalt atom is reduced by one electron, with similar effects
Toxicology 417:6473
However, it is important to note that despite completing six human clinical trials involving over 900 participants for its primary obesity indication, AOD-9604 failed to achieve statistical significance in its largest Phase IIb trial
The authors found the low-dose curcumin formulation to be effective for reducing inflammatory markers in older adults [62]
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