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a low ratio decreases IL-12 secretion which favors a Th2 response pattern over Th1 (a condition typically associated with chronic inflammation), while an elevated ratio favors a Th1 response ( The glutaredoxin (Grx) system, another key player, operates in close association with the GSH pool and serves primarily to regulate protein thiol redox status through reversible de-glutathionylation

Others exceed it for specific injury types

doi: 10.2337/dc12-2454 72 RosenstockJHanefeldMShamannaPMinKWBokaGMiossecPet al

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Liu et al., 2019