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The increased Bax/Bcl-2 ratio promotes mitochondrial outer membrane permeabilization and cytochrome c release, leading to the activation of caspase-9 and downstream executioner caspase-3 (78)

These therapies can provide targeted support, such as reducing oxidative stress, enhancing immune function, and improving symptom management and quality of life for patients

5A), cumulatively, Actinobacteria was the most abundant (42.24% 13.86%), followed by Firmicutes (35.38% 11.81%), Bacteroidetes (17.84% 6.71%), Euryarchaeota (2.83% 1.63%) and Proteobacteria (1.23% 1.76%), which explained the 99.5% of the phylum-level bacterial diversity

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Pharmacological concentrations of ascorbate radiosensitize glioblastoma multiforme primary cells by increasing oxidative DNA damage and inhibiting G2/M arrest