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Storage : Keep closed in a cool, dry place out of reach of children.

Aged mice also have hallmarks of BBB breakdown compared to young mice with increased leakage of IgG into the brain parenchyma, a reduction of the tight junction protein occludin, and a reduction in pericyte coverage and pericyte induced expression of genes in the endothelium [54, 90, 91]

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Adam L, San Lucas FA, Fowler J, Yu Y, Wu W, Liu Y, Wang H, Menter DG, Tetzlaff MT, Ensor JE, Manyam G, Arold ST, Huff CD, Kopetz S , Scheet P, Overman MJ