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These pairings tend to recur in the literature because their mechanisms dont overlap, allowing researchers to isolate each compounds contribution to a shared outcome

However, AAS are able to pass the blood-brain barrier and can directly affect the central nervous system (Bjrnebekk et al, 2017) so it would seem logical to suggest that there may be some structural impact that may lead to, or exacerbate, other issues such as psychological side-effects