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In clinic settings, emergency measures (like epinephrine and antihistamines) should be readily available in the rare event of an allergic reaction

The acetylated N-terminus slows renal clearance, extending the compound's half-life from approximately 90 minutes (GHK-Cu) to an estimated 68 hours (AHK-Cu) based on pharmacokinetic modeling

The regulatory environment may also evolve

Bhatt HR, James VHT, Besser GM, Bottazzo GF, Keen H Nicolas JP, Gueant JL, Frmont S

Lastly, if you're pregnant or nursing, HCG and B12 treatments are not recommended, so be sure to discuss your options with your doctor before beginning any regimen