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The approval is backed by positive findings from three Phase III trials, a Phase II dose-ranging study, and two Phase I pharmacokinetic studies

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SCs are extracted either from bone marrow or fat tissue and are sometimes used in conjunction with platelets

Each additional receptor target adds a new dimension of metabolic activity

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COPD also represents a substantial socioeconomic burden (US: $50 billion annual direct and indirect costs in 2010) 3