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3a, Supplementary Data 1)

Brighenti F, Casiraghi MC, Canzi E, Ferrari A

Inoculation and yeast propagation were performed in a medium containing potato wastewater enriched with glycerol (Avantor Performance Materials, Poland) in an amount of 5% (w/v)

Benefits may include: Increased energy and reduced fatigue Immune system support Stress relief and muscle relaxation Improved metabolism and circulation Support for headaches and tension

Ipamorelin : 2nd-generation GHRP, highly selective for GHS-R1a, no significant impact on cortisol or prolactin the current darling of modern protocols GHRP-6 : first generation, potent but triggers marked hunger (ghrelin-like action on the arcuate nucleus) and slight prolactin/cortisol elevation Hexarelin : most potent on acute GH release, but rapid GHS-R1a desensitization after prolonged use and more pronounced cortisol elevation Key point: GHRPs add an amplifying signal that potentiates GHRH, but chronic monotherapy triggers receptor down-regulation

Lausanne 8