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Under normoxic conditions, HIF-1 is rapidly degraded by PHD, but it accumulates when the PHD activity is repressed by low oxygen tension or iron chelators

Immunol Today, 16: 459-460

[DOI] [PubMed] [Google Scholar] 32.Di Marzo V, et al

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From debunking the Thanksgiving turkey makes you sleepy myth to explaining how creatine, red light, and sunlight impact brain function, sleep, and recovery, this episode dives deep into the biochemistry behind how the body actually works

In frail elderly patients or those with multiple comorbidities, clinicians may opt for even slower titration schedules or lower maintenance doses to balance efficacy with tolerability