semaglutide and ibs-d Digestive Health GLP-1 Medications: Is It Safe? Semaglutide bloating: why it happens,

The FDA's decision to include this boxed warning reflects the agency's conservative approach to potential carcinogenic signals, even when human relevance is uncertain

L.HulerW.SeydelT.KatsarasJ.RheinstdterM

The use of a GLP-1RA is indicated in patients with type 2 diabetes as monotherapy (if metformin is inappropriate), or in combination with other drugs (including insulin) if existing treatment fails to achieve adequate glycemic control [3-5]

All trials were multinational and sponsored by industry (two by Sanofi Aventis, three by Novo Nordisk, one by Eli Lilly, one by AstraZeneca, one by GlaxoSmithKline)

doi: 10.1016/S0140-6736(18)32590-X

B.WeuveJ.BarnesL