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Notably, LNP-based delivery method demonstrated significantly less Luc activity in non-liver organs, highlighting their superior liver selectivity (Supplementary Fig

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[6], [7] Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is the most prevalent chronic liver disorder worldwide, with an increasing incidence driven by the global rise in obesity and metabolic syndrome

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Furthermore, the concurrent addition of ICG-001 negated the amelioration of GLP-1 secretion by recovering NAD + levels, suggesting that Wnt signaling regulates GLP-1 secretion from L cells as a downstream mediator of NAD + biosynthesis