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Most patients experience peak nausea within the first 4872 hours after injection, with significant improvement by day 57 as their body adapts

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Monnier L, Colette C (2006) Addition of rapid-acting insulin to basal insulin therapy in type 2 diabetes: indications and modalities

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Another major use of methyl groups in the body is for the synthesis of phosphatidylcholine from choline, so when phosphatidylcholine levels are higher, there is less of a strain on the methylation cycle.[ref] Where is homocysteine produced

References 1 AlbistonA