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12,13,14,15,16,17 Unfortunately, for much of the subsequent 20th century, these concepts became superseded by the neurone doctrine, such that glial responses to CNS disorders were considered to be non-specific, stereotypic, always subsequent to primary neuronal damage and of little functional consequence

Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents

One of its most important roles is activating the enzyme manganese superoxide dismutase (MnSOD), which helps protect cells from oxidative damage

Hence, this review highlights the therapeutic controversies over the use of antioxidant supplements in cancer treatment

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In preclinical models it accelerates mucosal tissue repair, supports intestinal lining integrity, reduces markers of intestinal permeability, and promotes angiogenesis in gastrointestinal tissue