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The main benefit was the absence of side effects in those using myo-inositol ( Metformin and myo-inositol in women with PCOS 2019 )
In a controlled study, healthy adults who took 16 grams per day of oligofructose for two weeks showed increased colonic fermentation, higher plasma GLP-1 and PYY, lower post-meal glucose, reduced hunger ratings, and a measurable drop in total energy intake
Care must be taken to follow blood selenium levels as selenium deficiency and excess can both adversely affect glucose and lipid metabolism and potentiate the risk of development of type 2 diabetes in several animal studies, with less clear associations in human studies (148)
While peptide-based GLP-1R agonists such as semaglutide have transformed the treatment landscape, dual incretin receptor engagement further enhances metabolic outcomes
Metformin and phentermine are among the cheapest options
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