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In addition, this release is mediated as a result of changes in pH through the uptake of H + by ion channels such as polycystic kidney disease proteins 1 like 3 and 2 like 1 (PKD1L3, PKD2L1), inward rectifying K + channel (KIR2.1) and the epithelial Na + channel (ENaC) [4142434445]

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Mechanisms of Action Once ingested, L-theanine readily crosses the bloodbrain barrier, where it influences several neurotransmitter systems: Glutamate modulation : L-theanine interacts with glutamate receptors, dampening excessive excitatory signalling that can contribute to stress and mental overactivity

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Joshi M, Joshi A, Bartter T

12.5% c