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Indeed, two decades ago Reaven stated that although compensatory hyperinsulinemia may prevent the evolution of fasting hyperglycemia in individuals with IR, the price paid is NAFLD and the relevant atherogenic lipoprotein profile, which characterizes this population [139]

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An analysis of 26 studies (total 3020 patients) including 5 studies with psychiatric symptoms assessed as primary outcomes (for example, substance use disorders), and 21 studies with secondary outcomes, as well as an additional 10 registered clinical studies, was performed

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