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Verywell Health (2022)

How Tirzepatide Targets the Cycle of PCOS Weight Gain Tirzepatide is a dual agonist medication that targets two key hormonal pathwaysGLP-1 and GIPoffering profound benefits for the core issues underlying PCOS: Directly Improves Insulin Sensitivity: Tirzepatides dual action helps the body utilize insulin more efficiently

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Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis Via the Transcription Factor Foxo1

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The approval rests on the Phase 3 OASIS 4 trial, published in the New England Journal of Medicine