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Headaches are among the commonly reported side effects associated with glucagon-like peptide-1 (GLP-1) receptor agonists used for weight management in the UK

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This is called step therapy, and the medications that require it are listed as ST in the formulary

Following PSM, a total of 7392 individuals were selected, corresponding to 1848 patients for each of the four study groups (GLP-1 receptor agonists, SGLT-2 inhibitors, insulin and miscellany groups) (Table 1)

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While it offers significant promise as a therapeutic agent, its potential for pro-oxidant activity, organ-specific toxicity, and drug interactions necessitates careful consideration of dosing regimens and further research to establish safe and effective use