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THE END Attribution: Created by Ana Duff (Ontario Tech University), published under Creative Commons Attribution-NonCommercial-ShareAlike licence (CC-BY-NC-SA) Any modifications to this case study may affect its solvability and caution is advised.

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Articular cartilage deterioration and destruction is the hallmark of KOA, which affects all tissues of the knee joint (Loeser et al., 2012)

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