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Foundational strategies that remain essential include: Eating a whole-food, macronutrient-balanced diet Engaging in regular strength training to preserve lean muscle mass (12) Prioritizing sleep quality and circadian rhythm alignment (13) Supporting stress regulation and balanced cortisol signaling (14) Addressing gut dysfunction and chronic inflammation (15) Limiting refined sugar, alcohol, and inflammatory seed oils (16) When used without these foundations, appetite suppression alone may lead to short-term weight loss without improving long-term metabolic resilience

| 2023 | Int J Mol Sci, enzyme families involved in gene expression, stress response, and DNA repair, and a cofactor in the redox reactions that produce ATP