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A 2023 retrospective cohort analysis in JAMA Internal Medicine (N=16,922) found that patients on a GLP-1 RA plus an opioid had a 33% higher rate of bowel obstruction-related ED visits compared to patients on a GLP-1 RA alone [5]

c , d , representative 2 F o F c electron density contoured at 1.0 across the orthosteric peptide-binding pocket of GLP-1R