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In pursuit of a longer-acting drug, the Novo Nordisk team, led by Knudsen, created a once-daily liraglutide in the 2000s by structurally modifying human GLP-1 and adding fatty acid chains

These medications are often discussed because they affect appetite, fullness, and blood sugar, but they can also affect how quickly the stomach empties

For years, airtight patent protection in every major market kept generic competition completely off the table

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Like with any prescription drug, semaglutide can cause side effectsmostly gastrointestinal issues, like an upset stomach or constipation

Think of them as siblings with different personalities and skill sets