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Analyzing data from CVOTs can provide insights into the pathophysiologic mechanisms by which GLP-1RAs are linked to ASCVD and define the use of GLP-1RAs in clinical practice

Singh, A.P., Prabha, V., and Rishi, P., Indian J

Tirzepatide was used at 30 nM and the antagonists were used at 1M concentrations

The experiment was divided into a normal control group, a radiotherapy model group, and a radiotherapy+IGF-1 LR3 treatment group (1mg/kg, orally taken from the first day after radiotherapy, once a day, for 7 consecutive days)

Various compounds were used in order to examine the signaling components of IGF-1, including, tyrosine kinase inhibitors, PI3K inhibitors and LY 294002 inhibitors

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