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The mechanism(s) regulating the increased GH pulsatile component during fasting are still unclear

Nanoparticles face rejection by the mononuclear phagocyte system (MPS) which identifies foreign objects leading to reduced therapeutic effects

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Oxylipins regulate a broad range of physiological processes, including cell death, tissue repair, coagulation, cell proliferation, vascular permeability, pain, inflammation, immune functions, and blood pressure (55)

This can result in elevated drug levels in the bloodstream and increase the risk of toxicity