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We thank Joanna Loizou and Anna Schrempf for providing p53 mutant human TERT-immortalized retinal pigment epithelial 1 (RPE1) cells

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To quantify glutathione in both the oxidized and reduced forms, the GSH/GSSG-Glo Assay uses two reaction configurations to independently quantify GSH and GSSG (Figure 1)

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A pivotal 2023 randomized, double-blind, placebo-controlled clinical trial published in the prestigious Journals of Gerontology meticulously investigated the effects of GlyNAC supplementation in older adults suffering from severe glutathione deficiency and documented mitochondrial dysfunction