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But for now, the strongest evidence is still preclinical

Taking these medications long-term is associated with an increased risk of serious side effects such as heart attack, stroke, heart failure, gastrointestinal bleeding, ulceration, and perforation, kidney injury, potential liver strain, and serotonin syndrome

Respir Physiol Neurobiol ;266:121129

doi: 10.1016/j.autrev.2014.10.016 2 MaCZhongJZouYLiuZLiHPangJet al

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