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Because senescent cells can drive chronic, low-grade inflammation and impair tissue function, reducing their burden is a common goal in longevity research

Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: Effects of age, duration of illness and the translocation of LPS from gram-negative bacteria

Unwanted effects could be mild to severe, depending on the dosage

Some researchers hypothesize that the increased energy expenditure from glucagon activation means less of the caloric deficit needs to come from dietary restriction, which may be less catabolic to muscle tissue

2024, Jan, 19;383:6680 Qiu S, Cai Y, Yao H, Lin C, Xie Y, Tang S, et al

Being tired can be worse if your sleep is discombobulated or your stress is elevated