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Animal Studies As the name suggests, scientists perform this research in preclinical models (meaning before human trials), most commonly rodents
Diarrhoea is a common retatrutide side effect
Indeed, RYGB, which causes marked gastrointestinal distension due to how it forces food passage through the reconfigured gastrointestinal tract, leads to the same central pattern of neuronal activation as activating GLP-1R-expressing and OXR-expressing vagal afferents in mice [31, 36, 37], while vagotomy partially prevents the appetite suppression and weight loss caused by RYGB in rats [38]
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