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J Gerontol A Biol Sci Med Sci 61 (8), 806812

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Thats why its worth keeping tabs on how a drink makes you feel well before you get to that point, so you can know when its time to take a break or cut yourself off

Avoid caffeine and alcohol, as they dehydrate the skin and weaken its structure

Interestingly, selenium deficiency in rodents was found to have little impact on DIO activities as it appears that selenium is being supplied in priority for adequate synthesis of DIOs at the expense of other selenoenzymes (10)

doi:10.1024/0300-9831/a000237 Stubbendorff A, Kern S, Rydn L, Skoog I, Samuelsson J