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GLP-1 medications perform similarly or sometimes better

Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, et al

The decision to switch should involve shared decision-making between patient and clinician, considering HbA1c targets, weight management goals, cardiovascular risk profile, and individual preferences

This is particularly advantageous for patients who require continuous pain control, such as those recovering from major surgeries or managing chronic pain conditions

Nakamura T, Tanimoto H, Mizuno Y et al (2018) Gastric inhibitory polypeptide receptor antagonist, SKL-14959, suppressed body weight gain on diet-induced obesity mice

Patients should also be aware of potential hair loss , which affects some GLP-1 users due to rapid weight loss and caloric restriction rather than the medication itself