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Cognition in MCI and Alzheimer's disease: baseline data from a longitudinal study of the NTB

In one study, chronic treatment with a low dose of clozapine (0.5 mg/kg) increased the number of bromodeoxyuridine (BrdU)-positive cells in the dentate gyrus 24 hours after BrdU administration, whereas haloperidol (0.05 or 2 mg/kg) or a high dose of clozapine (20 mg/kg) had no significant effect.134 Interestingly, the increased BrdU-positive cells with a low dose of clozapine could not survive or integrate into existing hippocampal circuitry

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received a NHMRC Senior Research Fellowship (grant ID: 1155302) and a NHMRC Leadership grant (ID: 2026300)

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