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Finally, in clinical practice, some medications used to treat addiction can also affect appetite and body weight

Practical expectations should stay realistic

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Whether they will fulfil their potential extra-glycaemic effects described above will depend on the results of well-designed, long-term studies

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Mouse GIPR signaling on adipocytes is meaningfully different from human GIPR signaling, and the GIP-translation debate (whether GIPR agonism, GIPR antagonism, or some context-dependent mix produces the desired human metabolic effects) is genuinely unresolved in the field