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Skipping the off-period leads to diminishing returns as receptor sensitivity declines

They're injectable medications that come in pre-filled pens you administer as subcutaneous injections, in the fatty layer just under your skin

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Factors that should alert clinicians to possible nondiabetic aetiologies include an absence of retinopathy, duration of diabetes less than five years, acute kidney injury pattern of kidney dysfunction rather than gradual progression, presence of haematuria, other systemic disease or nephrotic syndrome (albuminuria greater than 3 g/day, low serum albumin level, oedema and symptoms such as frothy urine)