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subcutaneous or intramuscular delivery achieves systemic bioavailability for non-GI applications

With FDA-approval of the Wegovy pill by Novo Nordisk in December 2025, the first oral versions ofGLP-1 weight loss medications are scheduled to reach the market in January 2026

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Multimodal treatments tailored to different clinical presentations and potential underlying pathogenic mechanisms are recommended by current guidelines

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SIRT1 modulates lipid metabolism in the liver through the upregulation of PPAR [60]