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Senescent cells secrete increased levels of colony-stimulating factors, chemokines, and cytokines, e.g., GM-CSF, IL-6, IL-10, and TGF-, which can recruit and educate immune cells in aged tissues (see below)
Additionally, the pQCT findings imply that the enhanced cortical BMC might stem from an expanded cross-sectional bone area, suggesting that the femur and L6 vertebrae could have seen heightened bone mineralization
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Data from our laboratory has shown maximal absolute increases of between +17 to +41 mmolkg 1 dm (+59 to +200%), highlighting the range of change between individuals
This process involves proteins as cysteine source and iron