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As liraglutide and semaglutide induced stronger HbA1c reductions versus placebo then lixisenatide, it was important that the authors showed in reply to a letter to the editor that the anti-albuminuric effects were independent of glucose-lowering in post-hoc analyses

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However, patients on thyroid hormone replacement (levothyroxine) should monitor symptoms closely, as improved methylation can affect thyroid hormone conversion (T4 to T3)

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doi:10.1590/1981-863720180003000083517 Rostami R, Aghasi MR, Mohammadi A, Nourooz-Zadeh J