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GIP, GLP-1 and appetite: physiology and central nervous system mechanisms The approval of liraglutide 3 mg once daily for people with obesity was followed by the development of semaglutide 2.4 mg once weekly [79], resulting in up to 18% weight loss after 68 weeks [80]

To address the aforementioned limitations in current BBR-based obesity therapeutics, six strategic research priorities emerge: (1) Clinical Trial Optimization: a

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