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It is a canyon

For example, grapefruit may interact with heart medication, and antioxidants may interact with chemotherapy

Is it an indirect effect mediated through metabolic changes

Glycosaminoglycan from Apostichopus japonicus improves glucose metabolism in the liver of insulin resistant mice

MDM2 inhibitors Nutlins, which were identified by screening a synthetic chemical library, were the first compounds reported to inhibit the interaction between MDM2 and p53