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Makhija et al

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A clinically important limitation applies to all of this data: unlike oral semaglutide, which demonstrated cardiovascular outcome benefits in the SOUL trial, orforglipron has not yet completed a cardiovascular outcomes trial

Recent studies have also demonstrated that exendin-4 is mediated by Ca 2+ /calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/prolactin regulatory element binding (CaMKK/CaMKIV/PREB) pathway increases liver ABCA1 expression and reduces cholesterol accumulation [71]

Studies using GHRH antagonists showed that blocking hypothalamic GHRH largely eliminated the growth hormone response to GHRP-6