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This hypothesis was confirmed by several studies that had reported an important correlation between GSH levels and its positive effect on the active vitamin D ratio in the body where they showed that GSH deficiency is associated with increased oxidative stress where they epigenetically alter vitamin D regulatory genes and, as a result, the suppressed gene expression decreases vitamin D biosynthesis, ultimately leading to a secondary deficiency of vitamin D3

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Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity (in Eng)

West China 32 (6), 863867