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Umegaki, T., Yamada, Y., Ueda, A., Kuriyama, N

Characterising GH-specific skeletal anabolic responses in the absence of glucocorticoid-mediated bone resorption confounds introduced by non-selective GH secretagogue cortisol co-secretion

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Muscle contractility is determined by measuring the force of contraction caused by stimulation of frequency 10 Hz compared to the force of contraction caused by stimulation of frequency 100 Hz (maximum contraction force)

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In this case, a vicious cycle can happen where increased insulin levels drive an increase in glucose SGLT2 overexpression increasing glycemic levels which in turn will increment the insulin secretion (Figure 4C)