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Although preclinical studies have illustrated that pure nanotherapeutics possess some therapeutic functions, challenges still remain in their low accumulation at the targeted areas and easy leakage, which may cause therapeutic inefficiency to hinder subsequent clinical translation 23,24,25

Table 1 Efficacy of DPP-4 inhibitors in the clinical phase III programmes with at least 52 weeks duration as add on therapy to metformin compared to sulfonylureas

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