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J Comp Neurol 271:519532 Kakei M, Yada T, Nakagawa A, Nakabayashi H (2002) Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca2+ in rat nodose ganglion neurons

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The timeline varies given that multiple factors come into consideration, such as dosage amounts and frequency of use

This underscores the importance of understanding the long-term trajectory of tirzepatide therapy rather than looking for short-term boosts from additional medications