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People often notice the biggest benefit in areas like the forehead, crows-feet region, and around the mouth, where daily emotions create the strongest patterns

[PubMed: 2161738] 141

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The activation of the aforementioned non-canonical TGF--mediated signaling cascades have been implicated in the pathogenesis of fibrosis and fibrotic diseases including renal fibrosis, liver fibrosis, systemic sclerosis and osteoarthritis (107, 108)

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